Antithrombotic Drugs, Patient Characteristics, and Gastrointestinal Bleeding: Clinical Translation and Areas of Research

Gastrointestinal bleeding (GIB) is a potentially fatal and avoidable medical condition that poses a burden on global health care costs. Current understanding of the roles of platelet activation and thrombin generation/activity in vascular medicine has led to the development of effective antithrombotic treatments. However, in parallel with a sustained coronary and cerebral flow patency, the increasingly intensive treatment with warfarin; direct oral anticoagulant drugs [DOACs], and/or with aspirin ±clopidogrel (or ±prasugrel or ±ticagrelor), has increased the burden of GIBs related to the use of antithrombotic agents.
Source: Blood Reviews - Category: Hematology Authors: Source Type: research