Podocalyxin enhances breast tumor growth and metastasis and is a target for monoclonal antibody therapy

Conclusions: We show that podocalyxin plays a key role in the formation of primary tumors and distant tumor metastasis. In addition, we validate podocalyxin as potential target for monoclonal antibody therapy to inhibit primary tumor growth and systemic dissemination.

http://breast-cancer-research.com/content/17/1/46

Source: Breast Cancer Research - March 27, 2015 Category: Cancer & Oncology Authors: Kimberly SnyderMichael HughesBradley HedbergJill BrandonDiana HernaezPeter BergqvistFrederic CruzKelvin PoMarcia GravesMichelle TurveyJulie NielsenJohn WilkinsShaun McCollJohn BabcookCalvin RoskelleyKelly McNagny Source Type: research