FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth

Conclusions: FAK signaling occurs in the nucleolus, active FAK protects NS, and Akt-mTOR pathway regulates NS protein stability needed for breast carcinoma spheroid and tumor growth.

http://breast-cancer-research.com/content/17/1/47

Source: Breast Cancer Research - March 28, 2015 Category: Cancer & Oncology Authors: Isabelle TancioniNichol MillerSean UryuChristine LawsonChristine JeanXiao ChenElizabeth KleinschmidtDavid Schlaepfer Source Type: research