T160-phosphorylated CDK2 defines threshold for HGF-dependent proliferation in primary hepatocytes

In conclusion, we identified CDK2 phosphorylation as a gate-keeping mechanism to maintain hepatocyte quiescence in the absence of HGF.

Source: Molecular Systems Biology - March 14, 2015 Category: Molecular Biology Authors: Mueller, S., Huard, J., Waldow, K., Huang, X., D'Alessandro, L. A., Bohl, S., Borner, K., Grimm, D., Klamt, S., Klingmuller, U., Schilling, M. Tags: Cell Cycle, Quantitative Biology & Dynamical Systems, Signal Transduction Articles Source Type: research