Immunosuppressive therapies after heart transplantation — The balance between under- and over-immunosuppression

Since the first heart transplantation (HT) in 1967, survival has steadily improved. Issues related to over- and under-immunosuppression are, however, still common following HT. Whereas under-immunosuppression may result in rejection, over-immunosuppression may render other medical problems, including infections, malignancies and chronic kidney disease (CKD). As such complications constitute major limiting factors for long-term survival following HT, identifying improved diagnostic and preventive methods has been the focus of many studies.
Source: Transplantation Reviews - Category: Transplant Surgery Authors: Source Type: research