Non-controlled and over-the-counter drugs of abuse
2.5 out of 5 stars
Abuse of Medications That Theoretically Are Without Abuse Potential. Reeves RR et al. South Med J 2015 Mar;108:151-157.
Abstract
This review of noncontrolled prescription and over-the-counter drugs that can be and have been abused for non-medical or recreational purposes is rather sketchy and anecdotal (as the authors admit,) but nevertheless contains some useful information.
Classes of drugs discussed include:
Cold & Cough products: pseudoephedrine, ephedrine, oxymetazoline, dextromethorphan
Anticholinergics: diphenhydramine, benztropine, trihexyphenidyl (Artane)
Antipsychotics: quetiapine, olanzapine
Antidepressants: tricyclics, bupropion, fluoxetine, venlafaxine
Anitconvulsants: pregabalin, gabapentin
Muscle relaxants: carisoprodol, cyclobenaprine (Flexeril,) baclofen
Among the more interesting take-home lessons from tis paper :
bupropion is sometimes abused by nasal insufflation (snorting), thus bypassing first-pass metabolism and enhancing its cocaine-like effect at high doses [as the clip above shows, bupropion is also abused by injection]
dextromethorphan in large doses has dissociative and hallucinogenic effects similar to theses of phencyclidine (PCP) or ketamine
gabapentin and quetiapine have been reported to enhance the effects of Suboxone (buprenorphine/naloxone)
Source: The Poison Review - Category: Toxicology Authors: Leon Tags: Medical cough/cold preparations dextromethorphan medication abuse otc over-the-counter Source Type: news
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