Endometriotic mesenchymal stem cells exhibit a distinct immune phenotype

We report here that proliferation of PBMCs was less inhibited upon co-culture with ectopic MSCs compared with eutopic MSCs. The findings suggest that ectopic MSCs with increased levels of TLRs, collectins, pro-inflammatory cytokines and markers of migration and angiogenesis exhibit a distinct immune phenotype compared to eutopic MSCs. This distinct phenotype may be responsible for the reduced immunosuppressive property of ectopic MSCs and may be associated with the pathogenesis of endometriosis.

Source: International Immunology - March 23, 2015 Category: Allergy & Immunology Authors: Koippallil Gopalakrishnan Nair, A. R., Pandit, H., Warty, N., Madan, T. Tags: Original Research Source Type: research