CCR8 regulates contact hypersensitivity by restricting cutaneous dendritic cell migration to the draining lymph nodes

In this study, we found that Ccr8 –/– mice developed severer contact hypersensitivity (CHS) responses to 2,4-dinitrofluorobenzene, a murine model of ACD, compared with wild-type mice. T cells from Ccr8 –/– mice showed enhanced proliferative recall responses and Th1 and Th17 cell populations were expanded in these mice. However, CHS responses were similar between SCID mice adoptively transferred with Ccr8 –/– and wild-type T cells, suggesting that CCR8 in T cells is not responsible for the exacerbation of CHS. Notably, skin-resident dendritic cells (DCs), such as Langerhans cells and dermal DCs, and inflammatory DCs were highly accumulated in lymph nodes (LNs) of Ccr8 –/– mice after sensitization. Consistent with this, Ccr8 –/– antigen-presenting cells readily migrated from the skin to the draining LNs after sensitization. These observations suggest that CCR8 negatively regulates migration of cutaneous DCs from the skin to the draining LNs in CHS by keeping these cells in the skin.

Source: International Immunology - March 23, 2015 Category: Allergy & Immunology Authors: Yabe, R., Shimizu, K., Shimizu, S., Azechi, S., Choi, B.-I., Sudo, K., Kubo, S., Nakae, S., Ishigame, H., Kakuta, S., Iwakura, Y. Tags: featured content Source Type: research