Proteins involved in more domain types tend to be more essential.

In this study, we investigate what kind of proteins is inclined to be essential from a new perspective. The investigation implies that protein essentiality is correlated with protein domains, which are functional, structural and evolutionary units of proteins. Proteins with a larger Number of Domain Types (NDT) tend to be essential. The analyses on 22 species show that essential proteins identified by NDT are much more than those identified by ten random identifications. The consideration of the structural feature makes us less dependent on network data and thus enables us to investigate protein essentiality of more species with incomplete and/or inconsistent network data.
PMID: 25786790 [PubMed - in process]

Source: International Journal of Bioinformatics Research and Applications - March 21, 2015 Category: Bioinformatics Authors: Chen L, Cheng Y, Li M, Wang J Tags: Int J Bioinform Res Appl Source Type: research