Longer period of oral administration of aspartame on cytokine response in Wistar albino rats

Conclusion The findings clearly point out that aspartame acts as a chemical stressor because of increased corticosterone level and increased lipid peroxidation and nitric oxide level induce generation of free radicals in serum which may be the reason for variation of cytokine level and finally results in alteration of immune function. Aspartame metabolite methanol or formaldehyde may be the causative factors behind the changes observed.
Source: Endocrinologia y Nutricion - Category: Endocrinology Source Type: research