The role of mitochondrial DNA mutation on neurodegenerative diseases.
The role of mitochondrial DNA mutation on neurodegenerative diseases.
Exp Mol Med. 2015;47:e150
Authors: Cha MY, Kim DK, Mook-Jung I
Abstract
Many researchers have reported that oxidative damage to mitochondrial DNA (mtDNA) is increased in several age-related disorders. Damage to mitochondrial constituents and mtDNA can generate additional mitochondrial dysfunction that may result in greater reactive oxygen species production, triggering a circular chain of events. However, the mechanisms underlying this vicious cycle have yet to be fully investigated. In this review, we summarize the relationship of oxidative stress-induced mitochondrial dysfunction with mtDNA mutation in neurodegenerative disorders.
PMID: 25766619 [PubMed - as supplied by publisher]
Source: exp Mol Med - Category: Molecular Biology Authors: Cha MY, Kim DK, Mook-Jung I Tags: Exp Mol Med Source Type: research