Validation of the global resource of eczema trials (GREAT database)

Conclusions:
The sensitivity of the GREAT database for trials from 2000 onwards was high (75/88 trials, 94%). Sensitivity for the period prior to 2000 was less sensitive, due to differences in how the trials were identified prior to this time.‘Dual’ filtering for new records has recently become part of the GREAT database methodology and should further improve the sensitivity of the database in time. The GREAT database can be considered as a primary source for future systematic reviews including randomised controlled trials of eczema treatments, but searches should be supplemented by checking reference lists for eligible trials, searching trial registries and contacting pharmaceutical companies for unpublished studies.

Source: BMC Dermatology - March 14, 2015 Category: Dermatology Authors: Helen NankervisAlison DevineHywel WilliamsJohn IngramElizabeth DoneyFinola DelamereSherie SmithKim Thomas Source Type: research