Pleiotropic functions of the tumor- and metastasis-suppressing Matrix Metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic mice

Conclusions: These findings provide novel insight into the suppressive action of MMP-8 on mammary tumorigenesis and metastasis, and indicate that the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.

http://breast-cancer-research.com/content/17/1/38

Source: Breast Cancer Research - March 14, 2015 Category: Cancer & Oncology Authors: Julie DecockWouter HendrickxSally ThirkettleAna Gutiérrez-FernándezStephen RobinsonDylan Edwards Source Type: research