The Role of Aldehyde Oxidase in the Metabolic Clearance of Substituted Benzothiazoles

Conclusion: To our knowledge, such an observation of in vitro and in vivo oxidation of substituted benzothiazole by AO has not been reported before. The results helped the medicinal chemists design compounds that avoid AO-mediated metabolism and with better ADME property.
Source: Drug Metabolism Letters - Category: Drugs & Pharmacology Source Type: research