Investigating Protein Structure and Evolution with SCOP2.

Investigating Protein Structure and Evolution with SCOP2. Curr Protoc Bioinformatics. 2015;49:1.26.1-1.26.21 Authors: Andreeva A, Howorth D, Chothia C, Kulesha E, Murzin AG Abstract SCOP2 is a successor to the Structural Classification of Proteins (SCOP) database that organizes proteins of known structure according to their structural and evolutionary relationships. It was designed to provide a more advanced framework for the classification of proteins. The SCOP2 classification is described in terms of a directed acyclic graph in which each node defines a relationship of particular type that is represented by a region of protein structure and sequence. The SCOP2 data are accessible via SCOP2-Browser and SCOP2-Graph. This protocol unit describes different ways to explore and investigate the SCOP2 evolutionary and structural groupings. © 2015 by John Wiley & Sons, Inc. PMID: 25754991 [PubMed - in process]
Source: Current Protocols in Bioinformatics - Category: Bioinformatics Tags: Curr Protoc Bioinformatics Source Type: research