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We would like to thank Dr Jindal and coworkers for their interest in our work. Long story short, our manuscript describes a proof-of-concept study on the prognostic value of nonselective β-blocker (NSBB)-treatment-related (emphasis on “related”) changes in a noninvasive test (ie, von Willebrand factor antigen [VWF]). Although we find our hypothesis of VWF being a biomarker for nonhemodynamic effects of NSBB therapy very compelling, we have always abstained from claiming a causa l relationship. Indeed, the discussion section explicitly states that “a causal relationship … cannot be proven due to the design of our study.”
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Tags: Letters to the Editor Source Type: research