Integrative analyses identify modulators of response to neoadjuvant aromatase inhibitors in patients with early breast cancer

Conclusions:
These data provide a rationale for investigation of the role of CHKA in further models of de novo and acquired resistance to AIs, and provide proof of concept that integrative genomic analyses can identify biologically relevant modulators of AI response.

Source: Breast Cancer Research - March 11, 2015 Category: Cancer & Oncology Authors: Elena López-KnowlesPaul WilkersonRicardo RibasHelen AndersonAlan MackayZara GhazouiAradhana RaniPeter OsinAsh NerurkarLorna RenshawAlexey LarionovWilliam MillerJ DixonJorge Reis-FilhoAnita DunbierLesley-Ann MartinMitch Dowsett Source Type: research