Lectin RCA-I specifically binds to metastasis-associated cell surface glycans in triple negative breast cancer
Conclusions:
We discovered RCA-I, that bound to TNBC cells to a degree that is proportional to their metastatic capacities, found that this binding inhibits the cell invasion, migration, and adhesion, and identified a membrane protein, POTEF, that may play a key role in mediating these effects. These results thus indicate that RCA-I specific cell surface glycoproteins may play a critical role in TNBC metastasis and that the extent of RCA-I cell binding could be used in diagnosis to predict the likelihood of developing metastases in TNBC patients.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Shu-Min ZhouLi ChengShu-Juan GuoYang WangDaniel CzajkowskyHuafang GaoXiao-Fang HuSheng-Ce Tao Source Type: research