Palladium ‐Catalyzed Divergent Cyclopropanation by Regioselective Solvent‐Driven C(sp3)−H Bond Activation

AngewchemPalladium ‐Catalyzed Divergent Cyclopropanation by Regioselective Solvent‐Driven C(sp3)−H Bond ActivationDa Sol Chung, Jae Sung Lee, Ho Ryu, Dr. Jiyong Park, Hyunjoong Kim, Joo Hyun Lee, Dr. U Bin Kim, Prof.  Dr. Won Koo Lee, Prof.  Dr. Mu‐Hyun Baik, Prof.  Dr. Sang‐gi LeeA tandem palladium ‐catalyzed Heck/regioselective C(sp3) −H activation reaction for the divergent synthesis of spiro‐ and fused‐cyclopropanated indolines from N‐methallylated 2‐bromoarylamides. The regioselectivity of the C−H bond activation in the σ‐alkylPdII intermediate is controlled by the solvent used.

Source: Organometallic Current - October 26, 2018 Category: Chemistry Tags: Cyclopropanation Pd Catalyzed sp3 C-H Activation Source Type: blogs