Catalyst ‐Controlled 1,2‐ and 1,1‐Arylboration of α‐Alkyl Alkenyl Arenes

AngewchemCatalyst ‐Controlled 1,2‐ and 1,1‐Arylboration of α‐Alkyl Alkenyl ArenesAllison M. Bergmann, Stanna K. Dorn, Kevin B. Smith, Kaitlyn M. Logan Prof. M. Kevin Brown Two methods are reported for the 1,2 ‐ and 1,1‐arylboration of α‐methyl vinyl arenes. In the case of 1,2‐arylboration, the formation of a quaternary center occurred through a rare cross‐coupling reaction of a tertiary organometallic complex. 1,1‐Arylboration was enabled by catalyst optimization and occurred through a β ‐hydride elimination/reinsertion cascade. Enantioselective variants of both processes are presented as well as mechanistic investigations.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: boration Cu catalyzed Pd Catalyzed Source Type: blogs