Chiral Sulfide Catalysis for Desymmetrizing Enantioselective Chlorination

AngewchemChiral Sulfide Catalysis for Desymmetrizing Enantioselective Chlorination Qingxiang Cao, Jie Luo, Prof.  Dr. Xiaodan Zhao A chiral sulfide catalyzed the desymmetrizing enantioselective chlorination of various aryl ‐tethered diolefins and diaryl‐tethered olefins to afford teralins and tricyclic hexahydrophenalene derivatives, respectively, bearing multiple stereogenic centers. In contrast, the tertiary amine catalyst (DHQD)2PHAL led to a diastereomeric product. The products could be transformed into diverse compounds such as spiro ‐N‐heterocycles.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: Chlorination Desymmetrization Enantioselective organocatalysis Source Type: blogs