Access to All ‐Carbon Spirocycles through a Carbene and Thiourea Cocatalytic Desymmetrization Cascade Reaction

AngewchemAccess to All ‐Carbon Spirocycles through a Carbene and Thiourea Cocatalytic Desymmetrization Cascade ReactionShitian Zhuo, Tingshun Zhu, Liejin Zhou, Chengli Mou, Huifang Chai, Yunpeng Lu, Lutai Pan, Zhichao Jin, Prof.  Dr. Yonggui Robin Chi Harmony between cats: Dual carbene and thiourea catalysis enabled rapid asymmetric access to spirocyclic compounds by a desymmetrization process (see scheme). The presence of the thiourea cocatalyst was essential for this carbene ‐catalyzed enantioselective synthesis of all‐carbon spirocycles to proceed. The reaction products can be readily transformed into sophisticated multicyclic molecules and chiral ligands.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: All-Carbon Quaternary centers Desymmetrization Spirocycles Source Type: blogs