The Combination of Benzaldehyde and Nickel ‐Catalyzed Photoredox C(sp3)−H Alkylation/Arylation

AngewchemThe Combination of Benzaldehyde and Nickel ‐Catalyzed Photoredox C(sp3)−H Alkylation/Arylation M.  Sc. Lumin Zhang, M. Sc. Xiaojia Si, M. Sc. Yangyang Yang, M. Sc. Marc Zimmer, M. Sc. Sina Witzel, Dr. Kohei Sekine, Dr. Matthias Rudolph, Prof. Dr. A. Stephen K. Hashmi A combined approach: A simple and general strategy involving the combination of a photo ‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel) has been developed for the highly selective photoredox C(sp3) −H alkylation/arylation of ethers. A selective late‐stage modification of (−)‐ambroxide has also been conducted to demonstrate the applicability of the method.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: Alkylation Arylation Ni Catalyzed Sp3 Functionalization UV light Source Type: blogs