Rapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium ‐Catalyzed Asymmetric Cascade Hydrogenation/Reductive Amination

AngewchemRapid Construction of Structurally Diverse Quinolizidines, Indolizidines, and Their Analogues via Ruthenium ‐Catalyzed Asymmetric Cascade Hydrogenation/Reductive AminationYa Chen, Yan ‐Mei He, Shanshan Zhang, Tingting Miao, Prof. Dr. Qing‐Hua FanCascade reaction: A rapid construction of enantioenriched benzo ‐fused quinolizidines, indolizidines, and their analogues by ruthenium‐catalyzed asymmetric cascade hydrogenation/reductive amination of quinolinyl‐ and quinoxalinyl‐containing ketones is described. A range of chiral benzo‐fused aliphaticN‐heterocyclic compounds were obtained in good yields with excellent enantio‐ and diastereoselectivities (up to>99  %ee,>20:1 dr).

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: Hydrogenation Reductive Amination Ru catalyzed Source Type: blogs