Late ‐Stage Peptide Diversification through Cobalt‐Catalyzed C−H Activation: Sequential Multicatalysis for Stapled Peptides

AngewchemLate ‐Stage Peptide Diversification through Cobalt‐Catalyzed C−H Activation: Sequential Multicatalysis for Stapled PeptidesDr. M élanie M. Lorion, Nikolaos Kaplaneris, Dr. Jongwoo Son, Dr. Rositha Kuniyil, Prof. Dr. Lutz Ackermann C −H activation meets metathesis: Bioorthogonal C −H activation of peptides was accomplished by using air‐and moisture‐stable catalysts based on Earth‐abundant cobalt. This reaction set the stage for the combination of C−H functionalization and olefin metathesis to construct complex cyclic peptides.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: C-H Activation Co catalyzed Late Stage Functionalization Pd Catalyzed Peptide Modification Ru catalyzed Source Type: blogs