Palladium ‐Catalyzed Intermolecular [4+1] Spiroannulation by C(sp3)−H Activation and Naphthol Dearomatization

AngewchemPalladium ‐Catalyzed Intermolecular [4+1] Spiroannulation by C(sp3)−H Activation and Naphthol DearomatizationBojun Tan, Lu Bai, Pin Ding, Jingjing Liu, Yaoyu Wang, Prof.  Dr. Xinjun LuanTwo types of halides: A palladium ‐catalyzed [4+1] spiroannulation of two types of aryl halides has been developed for the rapid construction of a new class of spirocycles. This intermolecular domino process was realized through a sequence of C(sp3) −H cleavage, unsymmetrical biaryl coupling, and naphthol dearomatization.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: Dearomatization Pd Catalyzed sp3 C-H Activation Spirocycles Source Type: blogs