Ynamide ‐Mediated Thiopeptide Synthesis

AngewchemYnamide ‐Mediated Thiopeptide SynthesisJinhua Yang, Changliu Wang, Silin Xu, Prof.  Dr. Junfeng Zhao Effective to the backbone: In an ynamide ‐mediated two‐step procedure for thiopeptide bond formation, readily available monothiocarboxylic acids served as thioacyl donors. The appropriate balance between the activity and stability of α‐thioacyloxyenamide intermediates formed by the addition of the monothiocarboxylic acid to the ynamide enabled them to act as effective thioacylating reagents.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: Peptide Modification Source Type: blogs