Divergent Synthesis of Natural Derivatives of (+) ‐Saxitoxin Including 11‐Saxitoxinethanoic Acid

AngewchemDivergent Synthesis of Natural Derivatives of (+) ‐Saxitoxin Including 11‐Saxitoxinethanoic Acid Dr. James R. Walker, Dr. Jeffrey E. Merit, Dr. Rhiannon Thomas ‐Tran, Doris T. Y. Tang, Prof. J. Du Bois[2,3]=4 toxins: A synthetic strategy that enables access to four naturally occurring guanidinium toxins, namely saxitoxin, decarbamoyl saxitoxin, C13 ‐acetoxy saxitoxin, and C11‐saxitoxinethanoic acid, is detailed. Highlights of this work include an unusual Mislow–Evans rearrangement and a late‐stage Stille ketene acetal cross‐coupling reaction.

Source: Organometallic Current - January 10, 2019 Category: Chemistry Tags: Total synthesis Source Type: blogs