Review:The importance of synthetic chemistry in the pharmaceutical industry

ScienceThe importance of synthetic chemistry in the pharmaceutical industryBY KEVIN R. CAMPOS, PAUL J. COLEMAN, JUAN C. ALVAREZ, SPENCER D. DREHER, ROBERT M. GARBACCIO, NICHOLAS K. TERRETT, RICHARD D. TILLYER, MATTHEW D. TRUPPO, EMMA R. PARMEEChemical synthesis plays a key role in pharmaceutical research and development. Campos et al. review some of the advantages that have come from recent innovations in synthetic methods. In particular, they highlight small-molecule catalysts stimulated by visible light, enzymes engineered for versatility beyond their intrinsic function, and bio-orthogonal reactions to selectively modify proteins for conjugation. High-throughput techniques are also poised to accelerate methods optimization from small-scale discovery to large-scale production, and complementary machine-learning approaches are just coming into focus.
Source: Organometallic Current - Category: Chemistry Tags: Drug discovery Reviews Source Type: blogs