Palladium(II) ‐Catalyzed Enantioselective Azidation of Unactivated Alkenes

Palladium(II) ‐Catalyzed Enantioselective Azidation of Unactivated AlkenesXiaonan Li Dr. Xiaoxu Qi Chuanqi Hou Dr. Pinhong Chen Prof.  Dr. Guosheng LiuA Pd ‐catalyzed enantioselective intramolecular aminoazidation of unactivated alkenes using readily accessible 1 ‐azido‐1,2‐benziodoxol‐3(1H ) ‐one (ABX) as an azidating agent was established. This reaction affords a wide variety of structurally diverse 3‐N3‐substituted piperidines in good yields with excellent enantioselectivity, proceeds under mild reaction conditions, and features good functional‐group compatibility.

Source: Organometallic Current - August 5, 2020 Category: Chemistry Tags: Alkenes Azidation Enantioselective Pd Catalyzed Source Type: blogs