Chemo ‐ and Enantioselective Oxidative α‐Azidation of Carbonyl Compounds

Chemo ‐ and Enantioselective Oxidative α‐Azidation of Carbonyl CompoundsProf.  Dr. Muhammet Uyanik Dr. Naoto Sahara Mayuko Tsukahara Yuhei Hattori Prof.  Dr. Kazuaki IshiharaHigh ‐performance hypoiodite catalysis was developed for the chemoselective oxidative or decarboxylative oxidative α‐azidation of 1,3‐dicarbonyl compounds (see scheme). By this method, the late‐stage azidation of complex molecules with NaN3 and hydrogen peroxide as the azide source and oxidant, respectively, was possible under extremely mild conditions.

Source: Organometallic Current - August 6, 2020 Category: Chemistry Tags: Azidation Hypervalent Iodine Reagents Source Type: blogs