Untargeted metabolomics identifies succinate as a biomarker and therapeutic target in aortic aneurysm and dissection

ConclusionPlasma succinate concentrations allow to distinguish patients with AAD from both healthy controls and patients with AMI or PE. Succinate concentrations are regulated by the p38 α–CREB–OGDH axis in macrophages.
Source: European Heart Journal - Category: Cardiology Source Type: research