Pregnancy and pregnancy outcomes after hematopoietic stem cell transplantation in childhood: a cross-sectional survey of the EBMT Pediatric Diseases Working Party

AbstractSTUDY QUESTIONWhat are the characteristics of patients with conceptions transplanted in childhood and adolescence?SUMMARY ANSWERInsemination and conception after hematopoietic stem cell transplantation (HCT) in childhood or adolescence was possible, even after myeloablative conditioning regimes, although some patients required reproductive medicine support.WHAT IS KNOWN ALREADYPreparative regimens of HCT are highly gonadotoxic, which leads to gonadal failure and pubertal development disorders. There are few population-based studies assessing the risk of future infertility in children after HCT.STUDY DESIGN, SIZE, DURATIONWe conducted a retrospective study to investigate natural or assisted conceptions and their outcomes in patients<18  years old before their first transplantation who received HCT between 1995 and 2016 and were in the European Society for Blood and Marrow Transplantation (EBMT) registry. Adoptions were excluded from the analysis.PARTICIPANTS/MATERIALS, SETTING, METHODSDetailed information concerning pregnancy occurrences and outcomes were obtained by a separate questionnaire. Quantitative variables were presented as medians with their interquartile range (IQR) or range, and categorical variables were presented as frequencies and percentages.MAIN RESULTS AND THE ROLE OF CHANCEIn total, 62 988 pediatric patients received a first HCT in EBMT centers between 1995 and 2016. Pregnancy was reported in 406 patients in the database. The median age at trans...
Source: Human Reproduction - Category: Reproduction Medicine Source Type: research