Duodenal Mucosal Barrier in Functional Dyspepsia

In addition to gastric sensorimotor dysfunctions, functional dyspepsia (FD) is also variably associated with duodenal micro-inflammation and epithelial barrier dysfunction, the pathogenesis and clinical significance of which are unknown. Our hypothesis was that miRNAs and/or inflammation degrade epithelial barrier proteins resulting in increased duodenal mucosal permeability in FD.

Source: Clinical Gastroenterology and Hepatology - October 1, 2021 Category: Gastroenterology Authors: Susrutha Puthanmadhom Narayanan, Daniel R. O ’Brien, Mayank Sharma, Thomas C. Smyrk, Rondell P. Graham, Madhusudan Grover, Adil E. Bharucha Source Type: research