Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.

Functional Magnetic Resonance Imaging in Abstinent MDMA Users: A Review.
Curr Drug Abuse Rev. 2015 Mar 2;
Authors: Garg A, Kapoor S, Goel M, Chopra S, Chopra M, Kapoor A, Cann UM, Behera C
Abstract
Ecstasy or 3,4-methylenedioxymethamphetamine (MDMA) is a popular drug of abuse. In the animal studies MDMA has been shown to have deleterious effects on the serotonergic neurotransmitter system. Understanding the adverse effects of MDMA on human brain function is of considerable importance owing to the rising number of MDMA users. Various neuroimaging studies have investigated the structural, chemical and functional differences in the brain integrity of chronic MDMA users. Various neurocognitive domains like working memory, episodic memory, semantic memory, visual stimulation, motor function and impulsivity have been compared between chronic MDMA users and non-users using fMRI. The fMRI studies remain much more sensitive in studying the neurological deficits associated with chronic MDMA use as compared to the cognitive studies alone and therefore they serve as a prelude in our understanding of MDMA induced neurotoxicity. However they still face certain limitations contributing to inconsistency in the results and further research is needed before we can draw definitive conclusions regarding the neurotoxic effects of MDMA.
PMID: 25731754 [PubMed - as supplied by publisher]

Source: Current Drug Abuse Reviews - March 5, 2015 Category: Addiction Tags: Curr Drug Abuse Rev Source Type: research