Latest-analyses-Vitrakvi-larotrectinib-reaffirm-powerful-efficacy-tolerability-profile-adult

In an updated analysis on the adult subset of non-central nervous system (CNS) / TRK fusion cancer patients from three larotrectinib clinical trials, a high overall response rate (ORR) of 67% with a median duration of response (mDoR) of 49.3 months was observed as well as an extended progression-free survival (PFS; median of 25.8 months) as assessed by investigators / Post hoc sub-analysis of investigator-assessed ORR, DoR and PFS of patients (n=218) show uniformly high ORRs in patients regardless of prior treatment or performance status; highest response rates observed in patients receiving first-line larotrectinib (81%) and being Eastern Cooperative Oncology Group performance status (ECOG PS) 0 (85%) / Safety profile for larotrectinib continues to be consistent with that previously published; analysis on the incidence of fractures in larotrectinib trials shows no fracture related to larotrectinib based on investigator assessment / E-Poster published of a matching-adjusted indirect comparison (MAIC) evaluating efficacy (overall survival [OS], PFS, ORR including complete responses and DoR) and safety observed in clinical trials with larotrectinib compared to entrectinib. MAIC is an alternative method for comparative data when a head-to-head randomized control trial (RCT) is not available and/or possible, like for TRK fusion cancer which is an ultra-rare disease
Source: Bayer Company News - Category: Pharmaceuticals Source Type: news