Voriconazole, an Antifungal Triazol That Causes Visual Side Effects, Is an Inhibitor of TRPM1 and TRPM3 Channels [Visual Neuroscience]

Conclusions.
The visual disturbances associated with voriconazole are likely due to block of TRPM1 channels in retinal ON-bipolar cells. Other neurological effects of voriconazole may be due to block of TRPM3 channels expressed in the brain.

Source: Investigative Ophthalmology - February 25, 2015 Category: Opthalmology Authors: Xiong, W.-H., Brown, R. L., Reed, B., Burke, N. S., Duvoisin, R. M., Morgans, C. W. Tags: Visual Neuroscience Source Type: research