Intravitreal Delivery of Human NgR-Fc Decoy Protein Regenerates Axons After Optic Nerve Crush and Protects Ganglion Cells in Glaucoma Models [Glaucoma]

Conclusions.
Human NgR1(310)-Fc has favorable pharmacokinetics in the vitreal space and rescues large diameter RGC counts from increased IOP. Thus, the NgR1 blocking decoy protein may have efficacy as a disease-modifying therapy for glaucoma.

Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Wang, X., Lin, J., Arzeno, A., Choi, J. Y., Boccio, J., Frieden, E., Bhargava, A., Maynard, G., Tsai, J. C., Strittmatter, S. M. Tags: Glaucoma Source Type: research