The Effect of AMA0428, a Novel and Potent ROCK Inhibitor, in a Model of Neovascular Age-Related Macular Degeneration [Retina]

Conclusions.
The results suggest that targeting ROCK with AMA0428 not only reduces neoangiogenesis, but also blocks inflammation and fibrosis (contrary to VEGF suppression). These results point to a potential therapeutic benefit of ROCK inhibition in neovascular AMD.

Source: Investigative Ophthalmology - February 27, 2015 Category: Opthalmology Authors: Hollanders, K., Van Bergen, T., Kindt, N., Castermans, K., Leysen, D., Vandewalle, E., Moons, L., Stalmans, I. Tags: Retina Source Type: research