DNA Damage, Poly(ADP-Ribose) Polymerase Activation, and Phosphorylated Histone H2AX Expression During Postnatal Retina Development in C57BL/6 Mouse [Retinal Cell Biology]

Conclusions.
Oxidative DNA damage in postnatal retina increases during development. It is low during the first postnatal week when PARP-1 activity is high but increases thereafter. The rise in DSBs when PARP activity is downregulated may be attributable to accumulated oxidative damage and SSBs. At P7 and P14, -H2AX–positive cells are repairing naturally occurring DNA damage, but some are dying (mostly at P7), probably due to an accumulation of irreparable DNA damage.

Source: Investigative Ophthalmology - February 23, 2015 Category: Opthalmology Authors: Martin-Oliva, D., Martin-Guerrero, S. M., Matia-Gonzalez, A. M., Ferrer-Martin, R. M., Martin-Estebane, M., Carrasco, M.-C., Sierra, A., Marin-Teva, J. L., Calvente, R., Navascues, J., Cuadros, M. A. Tags: Retinal Cell Biology Source Type: research