Oxytocin Expression and Function in the Posterior Retina: A Novel Signaling Pathway [Retinal Cell Biology]

Conclusions.
Oxytocin and OXTR are present in the posterior retina, and OXT induces an increase in hfRPE [Ca2+]i. These results suggest that the OXT-OXTR signaling pathway is active in the retina. We propose that OXT activation of the OXTR occurs in the posterior retina and that this may serve as a paracrine signaling pathway that contributes to communication between the cone photoreceptor and the RPE.

Source: Investigative Ophthalmology - February 3, 2015 Category: Opthalmology Authors: Halbach, P., Pillers, D.-A. M., York, N., Asuma, M. P., Chiu, M. A., Luo, W., Tokarz, S., Bird, I. M., Pattnaik, B. R. Tags: Retinal Cell Biology Source Type: research