TPR Podcast Episode #8: Pearls from NACCT

Discussion of Dr. Millard Bass’ JAMA article “Sudden Sniffing Death” (SSD) SSD occurs after sniffing, bagging, or huffing a volatile hydrocarbon inhalant Hypothesis: death results from sensitization of the myocardium to catecholamines, resulting in cardiac arrhythmias   Capsaicin for Cannabinoid Hyperemesis Syndrome Initial idea to use capsaicin in the treatment of cannabinoidhyperemesis syndrome (CHS) stemmed from: Symptomatic relief from hot showers or baths often reported by patients Realization that TRPV1 receptor is activated by both hot temperatures and capsaicin Case reports from California and New York describing relief from CHS symptoms by application of capsaicin cream. Bonus fact: hotness of peppers measured in Scoville units.   Phenibut Phenibut (3-phenyl-4 aminobutyric acid): an OTC dietary supplement that is structurally similar to GABA, sometimes used as an anxiolytic and sedative Case reports of CNS depression and seizures as a result of overdose   Clenbuterol Clenbuterol is a non-FDA approved beta-2 adrenergic agonist not approved by the FDA but used to treat asthma in other countries Often abused by body builders for its purported sympathomimetic, lipolytic, and anabolic effects Case report of a body builder who overdosed on clenbuterol and developed hypokalemia, extreme hyperglycemia, hyperlactemia, and myocardial ischemia   Past Quizzler Q: What is the real identity of the Stay-Puft Marshmallow Man in the movie Ghostbusters? ...
Source: The Poison Review - Category: Toxicology Authors: Tags: Podcast cannabinoid hyperemesis syndrome capsaicin cream clenbuterol NACCT phenibut sudden sniffing death syndrome tpr podcast Source Type: news