Environmental heat stress modulates thyroid status and its response to repeated endotoxin challenge in steers

The objective of this study was to evaluate in cattle, the effects of acute exposure to a heat stress (HS) environment on the status of the pituitary (thyrotropin, TSH) – thyroid (thyroxine, T4) – peripheral tissue T4 deiodination (type 1 5’-deiodinase, D1; triiodothyronine, T3; reverse-triiodothyronine, rT3) axis and the further response of this pituitary-thyroid-peripheral tissue axis (PTTA) to perturbation caused by the induction of the proinflammatory innate immune state provoked by the administration of Gram-negative bacteria endotoxin (lipopolysaccharide, LPS).

Source: Domestic Animal Endocrinology - February 26, 2015 Category: Endocrinology Authors: S. Kahl, T.H. Elsasser, R.P. Rhoads, R.J. Collier, L.H. Baumgard Source Type: research