FOXF2 deficiency promotes epithelial-mesenchymal transition and metastasis of basal-like breast cancer

Conclusions: FOXF2 is a novel EMT-suppressing transcription factor in BLBC. FOXF2 deficiency enhances metastatic ability of BLBC cells by activating the EMT program through upregulating the transcription of TWIST1.

http://breast-cancer-research.com/content/17/1/30

Source: Breast Cancer Research - February 26, 2015 Category: Cancer & Oncology Authors: Qing-Shan WangPeng-Zhou KongXiao-Qing LiFan YangYu-Mei Feng Source Type: research