Downregulation of ALR impairs the therapeutic efficacy of LEPCs against acute liver injury by enhancing mitochondrial fission

In conclusion, we demonstrated that the transplantation ofALR-transfected LEPCs protected mice against CCl4-induced ALI, thus offering immense curative potential in the clinic.© AlphaMed Press 2021Significance StatementAugmenter of liver regeneration (ALR) is known to regulate mitochondrial dynamics in hepatocytes, thus offering protection against liver injury. However, whether ALR exerts a similar function in adult liver stem cells, thereby supporting cell transplantation in damaged liver with improved therapeutic efficacy, is not known. The results of the current study demonstrated that ALR was beneficial in LEPCs (liver epithelial progenitor cells), helping them combat liver injury after cell transplantation and offering immense curative potential in the clinic. The presented results aided in understanding the survival mechanism of liver stem cells regulated by ALR.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research