Combined histone deacetylase inhibition and tamoxifen induces apoptosis in tamoxifen resistant breast cancer models, by reversing Bcl-2 overexpression
Conclusion:
Our model implicates elevated ER and Bcl-2 as key drivers of anti-estrogen resistance, which can be reversed by epigenetic modulation through HDAC inhibition.
Source: Breast Cancer Research - Category: Cancer & Oncology Authors: Paromita RahaScott ThomasK ThurnJeenah ParkPamela Munster Source Type: research
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