Genetic depletion and pharmacological targeting of ¿v integrin in breast cancer cells impairs metastasis in zebrafish and mouse xenograft models

Conclusion:
These findings show that αv integrin is required for efficient TGF-β/Smad signaling and TGF-β-induced breast cancer cell migration, and for maintaining a mesenchymal phenotype of the breast cancer cells. Our results also provide evidence that targeting αv integrin could be an effective therapeutic approach for treatment of breast cancer tumors and/or metastases that overexpress αv integrin.

Source: Breast Cancer Research - February 25, 2015 Category: Cancer & Oncology Authors: Yihao LiYvette DrabschPhilippe PujuguetJiang RenTheo van LaarLong ZhangHans van DamPhilippe Clément-LacroixPeter ten Dijke Source Type: research