Photorhabdus Virulence Cassette as a causative agent in Photorhabdus asymbiotica

(Science China Press) PVC effectors Pdp1 (a new family of widespread dNTP pyrophosphatase effector in eCIS) and Pnf (a deamidase effector) are loaded inside the inner tube lumen in a " Peas in the Pod " mode. Moreover, Pdp1 and Pnf can be directly injected into J774A.1 murine macrophage and kill target cells by disrupting dNTP pools and actin cytoskeleton formation, respectively. The results provide direct evidence of how PVC cargoes are loaded and delivered directly into mammalian macrophages.

Source: EurekAlert! - Biology - July 13, 2021 Category: Biology Source Type: news