Angiogenesis-Interfering Potential of Wound Healing Plants in Subintestinal Blood Vessels of Tg(fli1a:EGFP)y1/+Zebrafish Embryos

Conclusion: The traditional xtracts (10–5 - 100 μg mL–1) in Hank’s solution containing dimethyl sulfoxide 0.1% (v/v) from 8 hrs post-fertilization (hpf) in ovo until 96 hpf ex ovo. Total SIV lengths were quantified using the Axiovision 4.8.1 Image Acquisition and Management Software. The numbers of surviving embryos were also recorded. Data were compared to those found with untreated controls (ANOVA, p<0.05). Results: None of the plant extracts produced greater SIV lengths than controls. However, the C. guianensis extract at 0.01 μg mL–1 produced a decrease of about 40% in SIV length and left about 70% of the embryos unharmeduse of the plants for wound healing may not involve proangiogenic events. However, the C. guianensis stem bark extract may possess antiangiogenic properties. This may impede wound healing but may be useful against conditions associated with excessive angiogenesis.
Source: Research Journal of Medicinal Plant - Category: Complementary Medicine Source Type: research