Hematopoietic Stem Cell Derived Functional Osteoblasts Exhibit Therapeutic Efficacy in a Murine Model of Osteogenesis Imperfecta

This study unequivocally establishes that transplanting HSCs can improve the clinical outcomes in OI due to the ability of HSCs to differentiate into osteoblasts, which lay down normal collagen. Therefore, HSC transplantation holds enormous translational potential and could become the therapy of choice for bone repair in OI and other bone diseases.

Source: Stem Cells - July 5, 2021 Category: Stem Cells Authors: In ‐Hong Kang, Uday K. Baliga, Yongren Wu, Shikhar Mehrotra, Hai Yao, Amanda C. LaRue, Meenal Mehrotra Tags: Regenerative Medicine Source Type: research